"My opinion is that it's all about politics. It's not anything to do with the riders," Nibali told Italian state TV Rai before the Strade Bianche Eroica race on Saturday in Tuscany.
"We've done a lot as riders and explained a lot. I'm not worried, but if our licence is suspended we'll have to go and ask for invitations to races. My professionalism isn't under discussion."
An audit by the Institute of Sport Sciences at the University of Lausanne (ISSUL) into Astana's management of anti-doping measures found "a big difference" between what the team committed to doing against doping, and what's actually happening, world cycling's governing body announced last week.
The UCI said there were "compelling grounds" to request that Kazakhstan government-backed Astana be stripped of its licence.
Astana received a probationary licence in December, after five senior and development squad riders were caught doping with EPO and steroids since August.
Without a WorldTour licence, Astana's admission to major races such as the Tour and Giro d'Italia would depend on invitations from race organisers.
"The race organisers know how dedicated we are in training and how many sacrifices we make at the races," Nibali said. "Their opinion will count a lot. If we lost our licence we can only hope to be invited to the races by the different organisers. But that's the worst case scenario."