Being imprisoned and awaiting execution by the Spanish Inquisition, Greek painter Domenicos Theotokopoulos (Nick Ashdon), known worldwide as El Greco, writes out his story. Born on the island of Crete, which was part of the Republic of Venice, he falls in love with Francesca (Dimitra Matsouka), daughter of the Venetian governor of Crete. But his father is preparing a political rebellion and as a result Domenicos leaves the island and moves to Venice, away from the young woman. There he meets the famous painter Titian (Sotiris Moustakas) and the Spanish priest Fernando Niño de Guevara (Juan Diego Botto). The latter, led by unrequited homosexual feelings for Domenicos, turns out a malevolent man and becomes the chief inquisitor in Domenicos' case, roiled by his emotions and resolute to revenge him.