Ms Rice is expected to face more questions over US treatment of detainees at a formal NATO meeting that is the final leg of a European trip in which she has faced criticism of US detention policies.
Allegations that the CIA had operated secret prisons in Europe and used European airports to secretly shuttle terrorism suspects to countries where they might be tortured have dogged Ms Rice on her trip.
European ministers had an initial discussion at a dinner ahead of Thursday's meeting, which included a contribution from Ms Rice.
"European ministers voiced their concerns that there should not be a different interpretation of international law," said Germany's Frank-Walter Steinmeier, arriving for a day of the NATO talks.
He added that the talks were open and he was happy with her contribution.
However Dutch Foreign Minister Ben Bot said he was "very satisfied" when asked whether he was happy with her explanations at the dinner.
Mr Bot has been one of the most concerned before the talks.
The European Union's British presidency has asked for formal clarification of US policy.
In an attempt to pre-empt pressure in Brussels, Ms Rice made a statement on the torture issue shortly before arriving in Brussels Wednesday afternoon, saying that Washington's obligations under an international convention prohibiting cruel, inhuman or degrading treatment "extend to US personnel wherever they are, whether they are in the US or outside the US."
"It is also US policy that authorised interrogation will be consistent with US obligations under the Convention Against Torture, which prohibit cruel, inhuman or degrading treatment," she said in Kiev.
Ms Rice herself made no comment as she arrived for the talks, which are set to focus on a deal to expand a NATO-led peacekeeping force into Afghanistan's more volatile south, where the US is keen for NATO to ease pressure on its stretched forces.
The United States has been taken to task over such techniques as "waterboarding," in which prisoners are strapped to a plank and dunked in water, made to fear they may be drowned.