The busty celebrity and animal rights campaigner has sent a letter to the chief of operations for the fast-food chain KFC complaining about the farming practices of the company's suppliers in Vietnam, according to People for the Ethical Treatment of Animal (PETA).
Ms Anderson protested against the mechanised slaughtering process - which she said makes chickens suffer needlessly through electric shock and scalding water - and also to selective breeding for birds that have large breasts.
"Chickens who are raised for KFC are bred and drugged to grow so large so quickly that many become crippled under their own weight," the former Baywatch star wrote to Pornchai Thratum, head of the 17 KFC outlets in Vietnam.
Ms Anderson said over-sized chicken breasts are no laughing matter. Often, the top-heavy chickens' legs break under the strain and they are left to suffer and die crammed in small pens with thousands of birds.
The actress has also participated in an explicit video, sent to KFC managers, showing what PETA says are inhumane farming methods of chickens.