Three key cabinet ministers, and long-standing allies of Mr Blair, have been mired in political and personal crises a week ahead of testing local elections.
He admitted that the job was "tough" at the height of one of the darkest weeks in his Labour government's nine years in power.
Mr Blair was faced with an admission of an extra-marital affair from his deputy, an apology from his home secretary for failing to deport foreign convicts, and his health secretary getting booed offstage for her glowing assessment of the National Health Service.
Mr Blair put on a brave face after what had said had been "not a great day".
However, he rejected comparisons with “Black Wednesday” when, in September 1992, the pound was forced out of the Exchange Rate Mechanism, a system for tying its value to that of other European currencies.
"When people talk about Black Wednesday, I remember it. Interest rates went up six percent and people lost their homes and jobs," a weary-looking Mr Blair told BBC television.
Asked about how yesterday had been for him, he said, "It is not a good day", adding that it had been worse for his ministers, "It is tough for them but then the job is tough. You know me well enough to know there's a resilience that will see through the next day's headlines"
"In this business, in the media culture that we have today, where there's no problem that isn't a crisis, no difficulty that isn't a catastrophe, no week that isn't going to end up being the most terrible thing that's ever happened, you do the job, you get on with doing the job.”
But there was little denying that with local council elections in England - a real-time test of Mr Blair's popularity - just seven days away, the trio of troubles risked sending his administration into meltdown.
"It is tough for them, but then the job is tough," he said of his beleaguered ministers.
Clarke apology
Home Secretary Charles Clarke kicked off a day of turmoil by apologising in parliament after it emerged that more than 1,000 foreign convicts in British jails were never considered for deportation after their release, as they should have been.
His plight was aggravated by the fact that 288 of the foreigners were freed after he was made aware of the problem last year. Mr Blair has rejected two offers from Mr Clarke to stand down.
Health Secretary Patricia Hewitt was humiliated on live television when she was mocked and heckled at a nurses' conference for asserting that the free-care-for-all National Health Service was having "one of its best years ever".
Ms Hewitt is in charge of overseeing controversial reforms to Britain's cash-strapped health care system that include laying off an expected 7,000 health professionals.
Deputy Prime Minister John Prescott also admitted to a two-year affair with a civil service secretary 24 years his junior.
New photos emerged of former merchant seaman Prescott - a political heavyweight known for his uncompromising and sometimes gaff-prone style, taking the secretary, Tracey Temple, to official functions and hoisting her in his arms at a Christmas party.
Mr Blair backed all his embattled ministers to carry on through their troubles.
He strongly defended Hewitt, who he said had "certainly not" offered to resign - "and nor should she".
"We are putting through difficult reforms in the health service," he insisted.
"I get used to this, people may shout and boo and heckle you and all the rest of it, but you've got to take the decisions that are right for country, otherwise you really shouldn't be doing the job."
Prescott affair
Mr Blair refused to discuss Mr Prescott's affair, but said his burly deputy - well known for his mangled English and punching a protester during the 2001 general election campaign - had not offered to quit either.
"That's a personal matter, and I'm not going to say any more about it. People can talk about it, but I'm not going to."
He said he had asked Mr Prescott "the questions I see appropriate" and was confident his number two has not broken the ministerial rules.
And he said it was right that Clarke stayed in his post to clear up the deportations crisis.
"To be fair to him, he is actually sorting it out now. I think he should get on and sort it out," Mr Blair said.
Political observers agree that if the crises drag through the weekend, and Mr Blair is seen to be helpless to control them, it could seriously harm Labour in next Thursday's local council elections.
The polls, centred on London and other big English cities, will be the first ballot-box test of Mr Blair's popularity since he led Labour to a third straight term in office in general elections a year ago.
If the party suffers big losses, it could hasten the day Mr Blair fulfils his pledge to stand down sometime during his third term to make way for his finance minister, Chancellor of the Exchequer Gordon Brown.