The message was needed "given Tehran's attitude and the acceleration of its (nuclear) programs," he said on the eve of a crucial International Atomic Energy Agency (IAEA) report on Iran’s nuclear program.
His remarks echoed a sharp line by his US counterpart, Condoleezza
Rice, who called on the Security Council to act against Iran.
"The situation is serious and worrying," Mr Douste-Blazy said. "There is nothing to suggest that Iran is conforming to the demands of the international community."
In Paris, a high-ranking diplomat said France was looking to invoke text in the UN Charter against Iran in a resolution that would open the way to the imposition of sanctions. The relevant chapter authorises the use of force against a country.
IAEA deadline
The head of the international nuclear watchdog is expected to report that Iran has failed to honor UN demands to stop enriching uranium.
The UN Security Council set Tehran a non-binding, 30-day deadline that runs out on Friday, to comply with its demands, which also call for full Iranian co-operation with IAEA inspectors.
Non-compliance could lead to sanctions against Iran, although Tehran's allies Russia and China, which are veto-wielding members of the Security Council major trading partners with the Islamic Republic, oppose such a move.
Iran's top nuclear official, Vice President Gholam Reza Aghazadeh, did not present any new proposals for solving the nuclear crisis during an 11th-hour meeting on Wednesday with Mohamed ElBaradei, the head of the IAEA.
They said there was almost no doubt that Mr ElBaradei's report would not be favorable to Iran.
"It is not going to be a good report. That is quite clear. What is there positive to report?" said a senior European diplomat, who asked not to be named due to the sensitivity of the issue.
Mr Aghazadeh, head of the Atomic Energy Organisation of Iran, "just rattled around on Iran's previously stated positions. He did not propose anything new," said another diplomat about the Iranian's meeting with Mr ElBaradei at IAEA headquarters in Vienna.
Iran defiant
Iran has stated clearly that it will not halt enrichment, which makes nuclear reactor fuel but what can also be the explosive core of atom bombs.
Iran's hardline President Mahmoud Ahmadinejad said on Thursday that his country would "not bow to injustice and pressure."
The United States claims Iran is using its civilian nuclear program as a cover for developing nuclear weapons. Iran says its atomic program is a peaceful effort to generate electricty.
Russian President Vladimir Putin said Thursday that the IAEA, which does not have enforcement powers, must retain the lead in resolving the standoff "and not unload this weight onto the back of the Security Council."
There was speculation here that Russia or China could call for an emergency meeting of the IAEA board of governors to review Mr ElBaradei's report.