After pro-Serbian opponents failed to file objections to the constitutional court, electoral officials validated results showing 55.5 percent of Montenegrins had voted to break from Serbia in the May 21 referendum.
Frantisek Lipka, the diplomat who heads the referendum commission, said it would likely present the final results to Montenegro's parliament formally on Saturday.
After receiving the results, the 70-seat assembly is expected to adopt a declaration of independence, asking other countries to recognise it.
Experts say a ceremony to inaugurate Montenegro's independence could take place on its national day, July 13.
The May 21 referendum effectively consigned former Yugoslavia to history, after the previous secession in the early 1990s of Bosnia, Croatia, Macedonia and Slovenia.
"Since there was no complaint from the unionist bloc to the Constitutional Court of Montenegro, we have fulfilled the conditions needed to communicate the result of the referendum," Mr Likpa told reporters in Podgorica.
The Serbian government of moderate nationalist Prime Minister Vojislav Kostunica -- who openly opposed Montenegro's independence -- is yet to react to Wednesday's results confirmation.
However the ultra-nationalist Serbian Radical Party, the single most popular political grouping in the republic, said it would do its utmost to help the Serbs who make up about 30 percent of Montenegro's 650,000 people.
Formal confirmation had been held up after pro-Serbian opposition parties, who had campaigned in favour of maintaining the loose federation with Serbia, alleged voting irregularities last week.
The announcement confirmed results released by the referendum commission last week showing 55.5 percent of Montenegrins opted for independence, barely above a European Union-agreed threshold of 55 percent.
But four days after the vote, the pro-Serbian parties lodged more than 200 complaints alleging incomplete registration, double voting and voters who had residency elsewhere.
Electoral officials rejected most of the charges, although the opposition camp had indicated it would only accept the will of the European Union.
EU Enlargement Commissioner Olli Rehn urged Serbia and Montenegro to agree an amicable split, saying both sides must adhere to standards agreed with the European Union over the dissolution of their federation.
"The referendum in Montenegro was a free and fair vote and it took place in an orderly manner, therefore there are all the reasons to consider it legitimate," Mr Rehn said on Tuesday on a visit to Belgrade.
"I trust that both Belgrade and Podgorica will engage in constructive negotiations on the practical conduct of the 'velvet divorce' without any unnecessary delays," he said.
Montenegro, wedged between the mountains and the Adriatic Sea, was the only former Yugoslav republic to remain in a union with Serbia after the others left during the brutal 1990s Balkan wars.
The referendum was made possible under an EU-brokered deal in 2003 that bound Serbia and Montenegro in a federation and contained an escape clause allowing either side to vote on independence after three years.