While Socceroos coach Guus Hiddink must decide how best to use Harry Kewell, who is struggling with fitness, back home in Australia fans will be deciding where best to party.
No matter what the result the Australian team has exceeded all expectations by making the round of 16 showdown.
Kewell hasn't trained since scoring the goal against Croatia that guided Australia into the knockout stage.
Hiddink is certain to use Kewell in some role and the coach has confirmed he will reinstate Mark Schwarzer as goalkeeper.
Sydney’s party
In Sydney, Australians of Italian descent will join an all night street party in the inner-western suburb Leichhardt.
Fans of both teams say Leichhardt is the place to be for the World Cup blockbuster, with more than five-thousand people expected to descend on the Italian heartland to watch the match live.
Giant screens
Meanwhile thousands more are expected to celebrate in Melbourne's Lygon Street.
Special bus services will run overnight to help ferry an expected 40,000 soccer fans home from central Melbourne following the Socceroos' historic match.
Two giant screens will be placed on Lygon Street in Carlton along with three other sites at Federation Square, Birrarung Marr and Telstra Dome.
Crowds will gather at the sites for the match kick-off at 1am (AEST).
Adelaide gets ready
Meanwhile Adelaide Oval will throw open its gates to Socceroos fans for the big clash.
The South Australian Cricket Association (SACA), with the support of the Adelaide City Council, will set up a big screen on the oval for soccer fans.
SACA chief executive Mike Deare said he hoped the event would attract a festive and vocal crowd.
"We see this as a great community event and, as such, are expecting a lot of families to come along and watch Australia take on Italy," he said.
The venue will be alcohol free but food and drink will be available.
Free parking will be offered, with gates opening at 11pm (CST) in time for the kick-off.