"The Iranian authorities say they are open to dialogue and ready to resume discussions," Mr Douste-Blazy told a meeting of French ambassadors.
"Without abandoning the demand to suspend sensitive activities, France is also ready to renew dialogue."
"But it must be a clear, concrete and responsible dialogue," he said.
"We want this dialogue quickly, with a desire for serious discussion and with the concern to finally find solutions to the Iranian nuclear problem," he said.
The UN Security Council has given Iran until August 31 to suspend uranium enrichment - which Tehran says is part of a civilian nuclear program – or face the threat of sanctions.
Western countries, led by the US, believe Iran wants to build nuclear weapons, but the Islamic republic insists it only wants to develop civilian nuclear power and has the right to master the required technology.
"At the moment, Tehran's response to proposals from the international community is not satisfactory," Mr Douste-Blazy said.
"It remains ambiguous and seems to continue to ignore essential question of sensitive nuclear activities, that is to say enrichment and reprocessing."
"This move is essential to re-establish confidence between all the parties to the negotiations," he told the ambassadors at their annual meeting in Paris.