• Russian Foreign Minister Sergei Lavrov has condemned a strike by the US-led coalition against Syrian pro-regime forces. (AAP)
US-led warplanes carry out a strike in Syria's east targeting a convoy of pro-government forces heading towards a garrison near the Jordanian border.
20 May - 7:59 AM  UPDATED 20 May - 10:40 AM

Russia has condemned a strike by the US-led coalition against Syrian pro-regime forces as "illegitimate" and said it could harm efforts to fight Islamic State jihadists.

"It is illegitimate, unlawful and yet another gross violation of Syria’s sovereignty," Russian Foreign Minister Sergei Lavrov said in televised comments while on a trip to Cyprus.

He added that Moscow was "concerned" that the "emerging understanding" of the need to unite efforts against the Islamic State group and the former Nusra front is "starting to erode".

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US-led warplanes on Thursday carried out a strike in the east of the country against a convoy of pro-government forces which were heading towards a remote coalition garrison near the border with Jordan.

In a statement, the coalition said it had struck "pro-regime forces … that posed a threat to US and partner forces."

The coalition said the strike came after unsuccessful "Russian attempts to dissuade Syrian pro-regime movement" as well as "a coalition aircraft show of force, and the firing of warning shots."

Lavrov said he was "unaware" that Russia had been given any warning of the strike, and said preliminary information suggested there were civilian casualties. 

"We are still confirming the details but according to some reports several dozen civilians died as a result of this strike," he was reported as saying by Russian news wires.

His comments echoed an earlier statement by a deputy, Gennady Gatilov, who said the coalition's strikes on Syrian forces were "unacceptable" and could hinder peace talks.

The Russian security council, chaired by President Vladimir Putin, discussed the strike later Friday.

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Spokesman Dmitry Peskov, quoted by Russian news agencies, said "it was stressed that such acts are illegitimate and considerably complicate the process of launching de-escalation zones."

Earlier this month, Russia, Iran, and Turkey, agreed to create four "de-escalation zones" across some of Syria’s bloodiest battlegrounds.

Russia and Iran have deployed forces to Syria to back up President Bashar al-Assad while the US and many of its regional and Western allies have called for the strongman to leave power.

The United States infuriated the Kremlin in April by bombing a Syrian air base in response to an alleged chemical attack by Damascus.

Representatives of Syria’s government and the opposition High Negotiations Committee met in Switzerland for the sixth round of UN-backed peace talks this week, but there was little progress.

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