Stage success seemed possible as the race entered Milan with former Australian champion Durbridge attacking with Etixx-Quick-Step's Iljo Keisse.
The pair held enough of an advantage over the disorganised peloton to contest the victory, with Keisse able to pip Durbridge for the stage spoil.
“We were always going to try,” said Orica-GreenEDGE sport director Matt White . “We tried, and it very nearly came off.
“Keisse is one of the best six-day riders in the world and in combination with Luke who is a time trial guru, it was a very good combination.
“We knew the circuit was tight and that it would be hard to organise a chase and there was also a few things that went in our favour in terms of certain guys puncturing and the like.”
Orica-GreenEDGE leave the race with two stage wins, three podiums and four days in the Maglia Rosa.
The team won the opening team time trial to put Simon Gerrans into the race lead. After Stage 2, it changed hands to Michael Matthews who went on to win Stage 3 during his two-day reign.
Finishing second behind a solo winner on stage four, Simon Clarke became the third Orica-GreenEDGE rider to pull on the jersey before Alberto Contador (Tinkoff – Saxo) asserted his control on the race.
“As I always say, it’s one thing to have goals and another thing to have the team to be able to achieve them,” White said. “But to have the Giro we have had, two years in a row, is very satisfying and all of the guys should be very proud.”
“People feel pressure when they don’t think they can achieve the end goal. When you are confident in the working group, confident in each other and confident in the work you have done that is a different type of pressure and something our team can handle.
“We know what we are capable of doing. We can’t win the Tour de France at the moment, we can’t win the Giro d’Italia at the moment, but what we can win is certain targets and that is a real strength of our team and our athletes.”