In the immediate aftermath of the bombings, organisers suggested the race may be cancelled but will now go ahead in solemn circumstances and subject to last minute changes on Government orders.
"For the moment, Dwars door Vlaanderen will take place, despite the terrorist attacks that took place in Brussels on Tuesday morning, organisers said in a statement.
"We mourn with the victims of these terrible acts. More information in due time."
The 200km race from Roselare to Waregem is the first in a jam packed peofessional calendar of races in Belgium which includes E3 Harelbeke, Gent-Wevelgem, Tour of Flanders and Liège-Bastogne-Liège.
"Security forces in Roeselare and Waregem have said the safety of the squad and the fans will be assured," organisers said.
Plans are now in place for a subdued depart. The riders will pay their respects to the victims and their families with a minute of silence and the podium ceremony will be adjusted to reflect the circumstances.
Despite the race going ahead, several teams may be unable to field a full roster due to disrupted travel plans, among them Giant-Alpecin, who announced they would not be attending.
Others like Belgian outfit Team Wanty-Gobert and Australia's Orica-GreenEDGE will have a full roster on hand for the race.