Britain's Chris Froome will attempt to become the first rider to claim the Giro d'Italia-Tour de France double for 20 years after confirming he would tackle both races in 2018.
Italian great Marco Pantani was the last man to achieve the feat in 1998, since when several greats have tried and failed.
Team Sky's Froome won the Tour de France for a fourth time in five years in July before going on to become the first Briton to claim victory in the Vuelta. If he wins the Giro he would be only the third rider to hold all three grand tour titles at once.
With the Giro and the Tour starting two months later Froome is taking on a daunting task, but he is confident he will be in optimum shape to rule in Rome and Paris.
"It's something the team have considered carefully and we've talked about a lot," the 32-year-old said in a statement.
"We know that it would be a significant feat in the modern era to win both the Giro and the Tour in the same season, but the way we managed things this year gives me confidence that I can successfully target both races."
Froome, who has not ridden the Giro since 2010 and is yet to claim the Maglia Rosa, could benefit from an extra week between the two races next year, owing to a slightly later Tour start due to the clash with football's World Cup in Russia.
The Giro, which will feature eight summit finishes and brutal climbing days in the final week, promises a fierce battle for the general classification with Froome up against twice former winner Vincenzo Nibali and 2017 champion Tom Dumoulin.
"It's a unique situation for me, having won the Tour and Vuelta and now having the opportunity to go to the Giro and attempt to win a third consecutive grand tour," Froome said.
"It's really exciting to be able to take on a new challenge, to do something that perhaps people wouldn't expect and to mix it up. It's a whole new motivation for me to see if I can pull off something special next year."
Stage one will be a 10.1km individual time trial in Jerusalem on 4 May, followed by road stages between Haifa and Tel Aviv (167km) and Beersheba and Eilat (226km).
The race will then head back to southern Italy with stage six featuring a climb of Mount Etna in Sicily on 10 May.
Eight summit finishes await Froome and the rest of the 2018 peloton, including two huge days in the mountains in the final week which could prove decisive in the battle for the Maglia Rosa, which promises to be one of the fiercest ever.
Stage 14 ends with the 22 percent gradients of Monte Zoncolan while stage 19 to the ski resort of Bardonecchia features the winding gravel roads of the Colle delle Finestre and a brutal 7.25km climb to the Jafferau ski station.
The 3,546.2km trek will end in Rome on May 27.