This year's Vuelta was originally scheduled to have three stages in the Netherlands, starting in Utrecht on August 14 before riders travelled south through Spain and Portugal for the rest of the three-week event.
However, event organisers Unipublic today announced that the official departure from the Dutch regions of Utrecht and North Brabant had been cancelled altogether.
"The departure of La Vuelta 20 from Holland was a project that had been designed as a big summer party," a statement read.
"Faced with the impossibility of ensuring the planned development of the race’s official departure, with all of the required guarantees for an event of these characteristics, La Vuelta Holanda has preferred to request the official departure’s cancellation."
La Vuelta Holanda director Martijn van Hulsteijn said logistical issues associated with autumn road works had contributed to the decision, one made with "great disappointment".
Organisers are already in talks for a return to the Netherlands in 2022, though no official date has been set.