Leigh was rumored for the role early on, and after meeting with other women, Tarantino appears to returned to the actress he originally wanted for the lead.
Kurt Russell, Samuel L. Jackson, Tim Roth and Michael Madsen (all of whom appeared at the recent reading of the script) are set to appear.
Shooting begins in early 2015.
Story revolves around a group of outlaws, bounty hunters and lawmen stranded by a blizzard in Wyoming when trouble ensues.
Leigh was most recently seen in "The Spectacular Now." She is repped by CAA.
TheWrap first reported the news.