Noah (Jonah Hill) has been suspended from college and has moved in back home with his mother. To make some quick cash, he agrees to babysit three young children - Slater (Max Records), Blithe (Landry Bender) and Rodrigo (Kevin Hernandez). Shortly after he's hired, though, Noah gets a call from a girl he is seeing (Dreama Walker) promising sex in exchange for drugs. Desperate, the irresponsible sitter packs his unsuspecting wards into the car and heads for the seedy part of town. Soon Noah becomes mixed up with two psychopathic drug dealers (Sam Rockwell and J.B. Smoove) and a wild chase through town.