He compared the project to the controversial Franklin Dam, a hydro energy proposal that sparked mass environmental protests and was eventually blocked.
"I cut my teeth on the Franklin campaign and that's a renewable energy project that was stopped in 1982," Dr Brown said.
"My history is not simply against polluting power, but is also against inappropriate renewable energy projects where they have massive impacts on the environment, not least the living species."
He has cited concerns about the size of turbines, the impact on views and dangers posed to migratory birds.
"The transmission lines are planned to cut through wild and scenic Tasmania, including the northeast Tarkine forests."
He also compared the project to poker machines.
"Like poker machines, everything has its limits," Dr Brown said.
"I support wind power but think this massive project which will power no Tasmanian homes, is too much a penalty scheme for the island."
His position puts the Greens, which have long campaigned for greater investment and government support for renewable energy, in an awkward position.
The Tasmanian Liberal Party accused Dr Brown, who has actively campaigned against the Adani coal mine, of "breathtaking hypocrisy".
"Dr Brown and the Greens have actively campaigned for the shutdown of the entire Australian coal industry and demanded we turn to renewables to deal with climate change," Energy Minister Guy Barnett told the Examiner.
"Such is his commitment to perpetual protest that he has now turned his sights to opposing renewables."
The Labor Party in Tasmania are also backing the wind farm proposal which it says will create sorely needed jobs.
Dr Brown hit back, saying senior Labor and Liberal figures should take a "deep breath" and release the project's economic cost-benefit analysis.
The Hong Kong-based proponent UPC Renewables has been contacted for comment.