Poverty shrinks kids' brains and is significantly more pronounced in children with stressful home environments whose parents lack nurturing skills.
Poverty in early childhood can shrink the brain, a study has shown.
The finding may help explain links between deprivation and poor mental ability and performance at school.
Scientists in the United States conducted magnetic resonance imaging (MRI) brain scans on 145 children aged six to 12.
They found that poverty was associated with smaller hippocampus and amygdala brain regions.
Both have roles in processing memory, and the amygdala is also linked to emotional reactions.
Amounts of grey and white matter were also lower in the brains of poor children.
Grey matter contains the cell bodies of neurons while white matter consists of the axons, or wiring, connecting different parts of the brain together.
The brain-shrinking effect of poverty was significantly more pronounced in children with stressful home environments whose parents lacked nurturing skills, the scans showed.
"We've known for many years from behavioural studies that exposure to poverty is one of the most powerful predictors of poor developmental outcomes for children," said Washington University child psychiatrist Professor Joan Luby.
"A growing number of neuroscience and brain-imaging studies recently have shown that poverty also has a negative effect on brain development.
"What's new is that our research shows the effects of poverty on the developing brain, particularly in the hippocampus, are strongly influenced by parenting and life stresses that the children experience."
The research is published in the latest online issue of the journal JAMA Pediatrics.
The children were recruited from a larger group taking part in a pre-school depression study.
As the children have grown, they have undergone MRI scans that track brain development.
"We actually stumbled upon this finding," said Prof Luby.
"Initially, we thought we would have to control for the effects of poverty, but as we attempted to control for it, we realised that poverty was really driving some of the outcomes of interest, and that caused us to change our focus to poverty, which was not the initial aim of this study."