"It's being done with the utmost safety requirements in place," Senator Birmingham said.
"We have successfully demonstrated, particularly states like South Australia, that they can return Australians from all corners of the world, safely quarantining them, and provide no exposure to the South Australian community in that process, so the same cautious and careful approach is being brought to bear when it comes to international students."
The university sector has been one of the hardest hit during the pandemic, with border restrictions preventing thousands of fee-paying international students returning to study since March.
Last month, Department of Home Affairs figures for the 2019-20 financial year revealed overseas student visa applications had plunged by more than 30 per cent.
The government resumed the processing of student visa applications lodged outside Australia last month in preparation for the reopening of borders.
They also announced a range of measures aimed at boosting international student enrolment, including allowing people who are unable to complete their studies within the timeframe of their original visa due to COVID-19 to lodge an additional application for free.
International students stuck overseas have been calling for a clear plan for when they would be able to return to Australia, many of who were partway through their degree when the border closed.
An earlier planned pilot program for 350 students to return to the Australian Capital Territory in July was scrapped after the onset of the coronavirus crisis in Victoria.
South Australian Premier Steven Marshall said the state's handling of coronavirus had put them in "the ideal position to be a first mover" in bringing back international students.
"International students are an important part of our community, adding to our state's vibrancy and multiculturalism," he said.
International students bring approximately $39 billion per year into the economy, making it Australia's fourth-largest industry.
Metropolitan Melbourne residents are subject to Stage 4 restrictions and must comply with a curfew between the hours of 8pm and 5am. During the curfew, people in Melbourne can only leave their house for work, and essential health, care or safety reasons.
Between 5am and 8pm, people in Melbourne can leave the home for exercise, to shop for necessary goods and services, for work, for health care, or to care for a sick or elderly relative. The full list of restrictions can be found here. All Victorians must wear a face covering when they leave home, no matter where they live.
People in Australia must stay at least 1.5 metres away from others. Check your state’s restrictions on gathering limits.
If you are experiencing cold or flu symptoms, stay home and arrange a test by calling your doctor or contact the Coronavirus Health Information Hotline on 1800 020 080. News and information is available in 63 languages at sbs.com.au/coronavirus.