"A number of politicians have come out and made Islamophobic comments directed at Muslims, directed at Islam," Mr Rauf told AAP.
"All of that creates a certain culture and gives a certain acceptance to that kind of language and conduct, especially when it's a person occupying a public platform and they express certain views."
Mr Rauf said he was speaking generally, although he noted some Liberal federal election candidates had been caught out by anti-Muslim comments.
The ANIC last month said Australia's political leaders and representatives needed to take steps to counter vilification and hatred, after independent senator Fraser Anning was censured by parliament for comments linking the Christchurch terror attack to Muslim immigration.
Mr Rauf said politicians had an obligation to avoid divisive conduct, rather than play on people's fears and insecurities.
"While it might win them some political points, if the effect of it is that it's causing certain communities within our society to be targeted, to be vilified, then that's a real concern and I think it needs to be called out.
"We've seen from Christchurch that words do have an effect and words do culminate in other things or at least embolden people to act upon a sense of hatred and vilification that might be expressed."
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Mr Rauf said the targeting of anyone in any place of worship was deeply distressing.
Sunday evening is the first night of the holy month of Ramadan, a time of self- reflection during which Muslims fast from sunrise to sunset.
The ANIC has encouraged the Muslim community to share the experience by inviting non-Muslims to join them in breaking their fast.