La La Land's Damien Chazelle won the directing Golden Globe ahead of Mel Gibson while Moonlight beat Hacksaw Ridge and Lion for best picture-drama.
It was a rough night for Australia at the Golden Globes with Mel Gibson, Nicole Kidman, Joel Edgerton and the films Hacksaw Ridge and Lion all snubbed.
La La Land was one of the big winners with multiple awards including Damien Chazelle beating Gibson (Hacksaw Ridge) for best director, while Viola Davis (Fences) won supporting actress ahead of Kidman (Lion).
Manchester by the Sea's Casey Affleck took the best actor in a drama ahead of Joel Edgerton (Loving).
Moonlight won the best film drama Globe at Sunday's ceremony that was highlighted by a passionate speech by Meryl Streep where she lambasted US president-elect Donald Trump while accepting the Cecille B DeMille Award lifetime achievement award.
La La Land, an ode to Los Angeles, is dominating the early film awards at the ceremony, winning a total of four statues including best actor in a musical or comedy for Ryan Gosling and best screenplay for Damien Chazelle.
When it came to television, Globe voters awarded newcomers Atlanta and Netflix's The Crown as the best comedy and best drama, respectively. Both shows are in their inaugural season.
Atlanta focuses on cousins navigating the rap scene.
"I really want to thank Atlanta and all the, like, black folks in Atlanta," said the show's creator Donald Glover. "Just for being alive."
The People v. O.J. Simpson: American Crime Story, a look at how the football star's murder trial divided the city of Los Angeles around racial lines, nabbed best TV movie or miniseries.
"American justice is anything but blind when race, gender and celebrity are involved," said producer Nina Jacobson in her victory speech.
Sarah Paulson won the Golden Globe for Best Actress in a Limited Series or TV Movie for her role in the show as Simpson's prosecutor, Marcia Clark.
"I feel like I'm going to faint," Paulson said. "To the man responsible for this, Ryan Murphy, you've changed my life."
"To Marcia Clark, you are an inspiration to me," she added.
Best actress in a TV comedy winner Tracee Ellis Ross used her time at the microphone to address Hollywood's poor track record with creating shows and films for people of colour.
"This is for all of the women, women of colour, and colourful people, whose stories, ideas, thoughts are not always considered worthy and valid and important," said Ellis Ross.
"I want you to know I see you, we see you."
As expected, Viola Davis picked up a best supporting actress award for her work as the wife of an egotistical garbage man in Fences.
She dedicated her award to her father, a worker on a race track with a fifth- grade education.
Aaron Taylor-Johnson won the first Golden Globe Award on Sunday, picking up a best supporting actor statue for his work as a criminal psychopath in Nocturnal Animals.
Billy Bob Thornton also picked up a best TV actor in a drama statue for his performance as an unconventional lawyer in Goliath.
In addition to nabbing the best TV drama award, The Crown won a a best actress in a TV drama statue for Claire Foy's performance as Queen Elizabeth II.
On stage, she called the queen "extraordinary," and said she "has been at the centre of the world for 63 years."
Host Jimmy Fallon got the show going with a nod to "La La Land's" opening number, but was hamstrung early in his opening monologue when his autocue broke down.
He turned it to his advantage though, later returning to say he had just gotten off the phone with Mariah Carey, who has been widely lambasted for a disastrous performance on New Year's Eve.
Fallon's opening monologue was peppered with several election-related zingers.
He compared US president-elect Donald Trump to King Joffrey, the mad monarch from Game of Thrones, and said that the Globes was one of the last places in America where the popular vote still mattered, a reference to how Hillary Clinton's popular vote win was meaningless in comparison to Trump's electoral college victory.
The Trump gibes weren't limited to Fallon. Meryl Streep, the winner of the Cecil B. DeMille award for career achievement, slammed Trump for having an "instinct to humiliate."
Best supporting actor in a limited series or TV movie victor Hugh Laurie joked that it would be the last Golden Globes broadcast because Hollywood, foreign and press were outlawed in Trump's America.
With a nod to his arms dealer character in The Night Manager, for which he won the award, he went on to say "I accept this award on behalf of psychopathic billionaires everywhere."
It was a good night for The Night Manager - in addition to Laurie, Olivia Colman nabbed a best supporting actress in a TV movie or limited series award and Tom Hiddleston picked up a best actor statue.