Argentine Higuain, who has scored 18 goals in all competitions for his club this season, picked up his fifth booking of the campaign in last week's 1-1 home draw with Genoa.
"Losing Gonzalo is important for us but we have to focus on our squad and make sure we are ready for the match," Napoli coach Benitez told a news conference on Saturday.
"Pandev, Callejon or Zapata can all do well. I have faith in them."
Napoli are six points behind second-placed AS Roma, who host Inter Milan later on Saturday, and 15 adrift of leaders Juventus who visit AC Milan on Sunday.
(Editing by Tony Jimenez) nL3N0LY07O