More than 125,000 people are currently hospitalised with coronavirus - another record - according to the COVID Tracking Project.
The country has begun a mass campaign of vaccinations and nearly 2.8 million people have already received their first jabs, a figure well behind the 20 million inoculations that the administration of President Donald Trump promised by the end of the year.
More than 12 million doses have been distributed nationwide, according to the Centers for Disease Control and Prevention, but efforts to vaccinate health workers and vulnerable people have been hampered by logistical problems and overstretched hospitals and clinics.
President-elect Joe Biden, who takes office on 20 January, has criticised the troubled vaccine rollout, and this week confirmed that he would invoke the Korean War-era Defense Production Act to force private industry to step up production for the government.
He has implored Americans to wear masks to slow the spread of COVID-19 and said he would impose a mandate on face coverings in areas where the federal government has jurisdiction, such as airplanes.
'We owe them'
Paying tribute to US health care workers on New Year's Eve, Mr Biden said "they stepped up and they are brave. They have done so much for us, and we owe them."
Under Mr Trump, US authorities have given often mixed messages on mask-wearing, social distancing and shutdowns, and the outgoing president has repeatedly downplayed the risks while cases have rocketed across the country.
In his New Year's Eve message, Mr Trump hailed the "medical miracle" of coronavirus inoculations, adding "our most vulnerable citizens are already receiving the vaccine, and millions of doses are quickly being shipped all across our country."
According to Johns Hopkins, the US took several months to reach 10 million cases on 9 November, before accelerating to 20 million cases on Friday.
After the US, the hardest-hit countries are Brazil with 194,949 deaths from 7,675,973 cases, and India with 148,994 deaths from 10,286,709 cases.
People in Australia must stay at least 1.5 metres away from others. Check your jurisdiction's restrictions on gathering limits. If you are experiencing cold or flu symptoms, stay home and arrange a test by calling your doctor or contact the Coronavirus Health Information Hotline on 1800 020 080.
News and information is available in 63 languages at sbs.com.au/coronavirus. Please check the relevant guidelines for your state or territory: NSW, Victoria, Queensland, Western Australia, South Australia, Northern Territory, ACT, Tasmania.