The 28-year-old has denied all charges relating to the incident with a woman in Melbourne last year and plans to defend himself in court.
Creek has emerged as an MVP candidate this season, having led the Phoenix to a 9-7 record off the back of 21.19 points, 7.25 rebounds and 3.69 assists per game.
Nevertheless, after "urgent discussions" with both Basketball Australia's integrity unit and the players' union, the NBL have since confirmed the swingman will neither train nor play until further notice.
It is believed Creek left the woman with significant facial injuries and, according to The Age, has been charged with unlawful assault, along with intentionally and recklessly causing injury.
In a statement released by the NBL, the league said they were "deeply concerned by the nature of the charges" and will "take this matter extremely seriously".
"The NBL and South East Melbourne Phoenix have held urgent discussions with the Australian Basketball Players’ Association and Basketball Australia’s Integrity Unit in respect of the allegations.
"The NBL and South East Melbourne Phoenix also understand that Mitch Creek denies each of the charges and will deal with the matter appropriately through the court process.
"As the body responsible for enforcing the national integrity framework which covers NBL players, Basketball Australia’s Integrity Unit has undertaken a preliminary investigation into the matter.
"The NBL, South East Melbourne Phoenix and Mitch Creek have all agreed that he will not train or play with the club until further notice.
"As the matter is before the courts, the NBL and South East Melbourne Phoenix will not make any further comment for now."