The team will be spearheaded by dual Paralympian Ellie Cole who broke the eight year old S9 50m freestyle world record at the Adelaide trials.
The 24-year-old is also the current world champion in the event.
"For 50m freestyle - leg amputees aren't very good at it," Cole said.
"Natalie du Toit held the record before and to follow in her footsteps has been a dream of mine.
"I've been on the Australian swim team for 10 years now and performances like that just really remind you of what it is all about."
The squad's other women's world record breaker in Adelaide was 14-year-old Paralympic debutant Tiffany Thomas Kane (S6 50m breaststroke).
The full Australian Paralympic Swimming Squad:
Tiffany Thomas Kane