According to a new countdown compiled by Britain's Official Charts Company and unveiled by BBC Radio 1, the track Blurred Lines - which also features vocals from TI and Pharrell Williams - has sold a record-breaking 1.54 million copies since it was released last May.
The best-selling single of 2013, it was banned at several universities and was the subject of campaigns from women's rights groups after some said the lyrics were derogatory and sexist.
The track was accompanied by a video in which Thicke was surrounded by naked dancing models, prompting some to call for age ratings to be applied to pop tracks.
Blurred Lines overhauls the previous biggest selling download, Adele's Someone Like You, which has sold 1.53 million copies to date. The all-time top five is completed by 2011's Moves Like Jagger by Maroon 5 featuring Christina Aguilera, Somebody That I Used To Know by Gotye featuring Kimbra released the same year, and I Gotta Feeling by Black Eyed Peas, which was first released in 2009.