Maria Sharapova's withdrawal from the US Open will bring welcome relief to Australia's Daria Gavrilova.
The Melburnian was due to meet the tournament's No.2 seed in the opening round but will now meet lucky loser Daria Kastkina.
Five-time major champion Sharapova pulled out on the eve of the tournament citing a leg injury.
The Russian has not played a match since losing to Serena Williams in the Wimbledon semifinals in July.
She withdrew from hard-court tournaments in Toronto and Cincinnati in August, citing a right leg strain.
"Dealing with these nagging things, it's almost like a day-to-day process," Sharapova said. "When you are facing something with the body it's always a day-to-day process.
"I've done everything I could to be ready. "There's nothing more that I could have done."
It's the second time in three years that the 2006 champion has withdrawn from the year's last Grand Slam event.