Projections showed Macron widening his centrist revolution, with his Republique en Marche (Republic on the Move, REM) party and its ally MoDem tipped to win between 400 and 445 seats in the 577-member National Assembly in next Sunday's second round.
Such a share would give Macron one of the biggest parliamentary majorities for 60 years.
"France is back," Prime Minister Edouard Philippe declared triumphantly.
"For the past month, the president has shown confidence, willingness and daring in France and on the international stage," Philippe said, calling the result a vindication of Macron's "winning strategy".
But the vote was marked by record low turnout of 49 percent, possibly reflecting fatalism among Macron's opponents in the face of his seemingly unstoppable advance, experts said.
