The shooting took place at the First Baptist Church in Sutherland Springs, 65 kilometres east of San Antonio, during its mid-morning Sunday service.
The assailant, believed to be a 26 year-old white male, was found dead from a bullet wound in his car a short distance away.
Reports indicate a number of children are among those killed, including the 14 year-old daughter of one of the church's pastors.
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