Malaysia Airlines flight MH17 was travelling between Amsterdam and Kuala Lumpur in July 2014 when it was shot down as it flew over conflict-hit Ukraine.
Russia and Ukraine were at odds over territory along their shared border.
All 298 people aboard died and their supporters have been pursuing justice ever since, amid suspicions the plane had been attacked by Russian-backed separatists.
Now, international arrest warrants have been issued for four suspects - three Russians and one Ukrainian.
Each suspect faces two criminal charges: firstly "crashing flight MH17, resulting in the death of all passengers,"; and secondly, "the murder of the 298 occupants of flight MH17".