Curtis Good, Adrian Luna and Rostyn Griffiths netted for the home side, while Jordan Murray struck a late consolation for the Mariners.
The victory sees City secure top spot by three points, with Western Sydney to play on Saturday night.
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Melbourne City have defeated Central Coast Mariners 3-1. Source: Getty Image
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By SBS Sport
Presented by Yang J. Joo
Source: AAP, SBS