The Sky Blues ran rampant in front of a crowd of 61,880 at the Olympic venue where former Besiktas teammates Bobo and Filip Holosko seamlessly scored the first two goals before whizzkid Brandon O'Neill executed an exquisite 85th-minute free-kick and substitute Alex Brosque completed the rout with one minute remaining.
It was the biggest Sydney derby win in the fixture's history and means the Wanderers will have gone winless for three years and three days by the time they get another chance on January 14.
Saturday was a rowdy and entertaining night brimming with class and magnificent displays from Sky Blues goalkeeper Danny Vukovic and wriggling Wanderers winger Jumpei Kusukami.
But it belonged to the Sky Blues, who were rampant and irrepressible, their clever movement and slick delivery too much for Tony Popovic's men.
Sydney had the better run from the start as Western Sydney lacked the midfield composure Andreu had provided last season.
The battle came to life on 30 minutes when Robert Cornthwaite clattered into Bobo and instigated an old-fashioned melee.
The towering centre-back got to the ball, but was lucky not to have been sent off for the challenge, which earned him a yellow card.
Scott Neville and David Carney copped the same for their role in the aftermath, in which a livid Popovic exchanged verbals with Sydney's coaching staff.
If anything, the flashpoint sparked the Wanderers and they came on the counter with venom.
