Tottenham kick-started their Group B campaign with a 5-0 triumph when the sides met in London two weeks ago and were again comfortable winners at Rajko Mitic Stadium on Thursday.
Giovani Lo Celso's maiden goal for the club was added to by a second-half double from Son, who started for Tottenham just three days on from being left distraught by a challenge that preceded Andre Gomes' horrific injury in the 1-1 Premier League draw with Everton.