Nicole Kidman has won Best Performance by an actress in a limited series or a motion picture made for television.
Kidman took home the award for her role in Big Little Lies in which she played a woman in an abusive relationship.
"The character I played represents something that is the centre of our conversation right now - abuse," she said during her acceptance speech.
"I do believe and I hope we can elicit change through the stories we tell and the way we tell them. Let's keep the conversation alive, let's do it."
Kidman paid tribute to the "power of women" and to her mum, who she says was an advocate for women's rights.
"Because of her, I am standing here. My achievements are her achievements," she said.
Kidman's win came moments after the show opened with host and Saturday Night Live alumni Seth Meyers drawing light on the harassment scandal that has subsumed Hollywood
"Good evening ladies and remaining gentlemen," he said, adding, "It's 2018, marijuana is finally allowed and sexual harassment isn't."
Meyers also referenced the seemingly endless parade of allegations involving famous men that have dominated headlines.
And he did not waste time in addressing the elephant in the room, or rather the elephant "not in the room", as he phrased it.
"Harvey Weinstein isn't here tonight because well, I've heard rumours he's crazy and difficult to work with," Meyers said.
Winners of the night
James Franco won the Golden Globe for best actor in a musical or comedy film for "The Disaster Artist," his portrayal of the director of one of the most panned movies in history.
Franco triumphed in a field that included Daniel Kaluuya, the star of the racial thriller "Get Out," and Steve Carell for his portrayal of chauvinistic tennis champion Bobby Riggs in "Battle of the Sexes."
Winning his second Golden Globe, Franco brought to the stage the man he portrayed, Tommy Wiseau, maker of the disparaged 2003 film "The Room."
"This was billed as a movie about making the best worst movie ever made but, in fact, it's a story of friendship," Franco said, with Wiseau at his side.
Sam Rockwell won the Golden Globe for best supporting actor for his role as an angry police officer in the dark comedy Three Billboards Outside Ebbing, Missouri.
Rockwell bested Willem Dafoe (The Florida Project), Armie Hammer (Call Me by Your Name), Richard Jenkins (The Shape of Water) and Christopher Plummer (All the Money in the World).
Winning a Golden Globe for the first time, Rockwell noted he had often starred in indie films and said: "It's nice to be in a movie that people see."
Allison Janney on Sunday won the Golden Globe for best supporting actress for playing the mother of disgraced figure skater Tonya Harding in I, Tonya.

Sam Rockwell poses in the press room with the award for best performance by an actor in a supporting role in any motion picture (AAP) Source: AAP
The other contenders included another actress playing a mother, Laurie Metcalf in "Lady Bird," and Octavia Spencer for the night's most-nominated film, "The Shape of Water."
Mexican filmmaker Guillermo del Toro took home his first Golden Globe on Sunday for directing acclaimed fantasy romance The Shape of Water.
In what was deemed one of the closest categories going into the night, Del Toro beat Martin McDonagh (Three Billboards Outside Ebbing, Missouri), Christopher Nolan (Dunkirk), Ridley Scott (All the Money in the World) and Steven Spielberg (The Post) to the prize.
Oprah Winfrey took home the Cecil B. de Mille lifetime achievement award.
In her speech, she declared a "new day" for women and girls facing down abusive men.
"For too long, women have not been heard or believed if they dare speak the truth to the power of those men. But their time is up! Their time is up!" Winfrey said to a standing ovation and even some tears in the audience.
German neo-Nazi thriller In the Fade won the Golden Globe for best foreign language film and Irish actress Saoirse Ronan took home best actress in a musical or comedy for Lady Bird, which also won best comedy.
Hollywood veteran Gary Oldman won best actor in a film drama for Darkest Hour and Three Billboards Outside Ebbing, Missouri snagged best motion picture - drama award.
Three Billboards actress Frances McDormand was triumphant in the best performance by an actress in a motion picture - drama category.
Stars wear black
Turning the Globes dark on the fashion front had been anticipated for days after a call for massive reform following the downfall of movie mogul Harvey Weinstein and numerous others accused of sexual misconduct in Hollywood, media, fashion, tech, publishing and other industries.
Oscar-winning actress Meryl Streep, accompanied by domestic violence advocate Ai-jen Poo, said she chose black to stand in solidarity with others trying to right the power imbalance that leads to sexual abuse.
The new initiative Time's Up,
backed by more than 300 women in Hollywood, doled out badges intended in part for those who might already have locked in more colourful looks.

Amy Poehler, left, and Saru Jayaraman arrive at the 75th annual Golden Globe Awards Source: AP
Not everybody supported the protest. Rose McGowan, who accused Weinstein of rape, had loudly and persistently called the effort an empty gesture
Red Carpet
Stars of film and television have begun making their way onto the red carpet and as expected, many are dressed head-to-toe in black.
Laura Dern, Amy Poehler, Susan Sarandon, Meryl Streep, Emma Stone, Emma Watson, Michelle Williams and Shailene Woodley all vowed to be accompanied by prominent female activists across a range of fields.
The move is part of their push to raise awareness for victims of sexual assault and harassment.
Meryl Streep's date is Ai-jen Poo, the director of the National Domestic Workers Alliance and co-director of the Caring Across Generations Campaign.
Michelle Williams has been joined by the founder of the #metoo movement, Tarana Burke.
Susan Sarandon brought journalist and activist Rosa Clemente, whose focus is political prisoners, voter engagement among youth of colour and media justice.
Emma Watson arrived with Marai Larasi, the founder of UK-based black feminist organisation Imkaan.

Meryl Streep, left, and Ai-jen Poo arrive at the 75th annual Golden Globe Awards Source: AP
Full list of Golden Globe winners:
FILM
Best film, drama: Three Billboards Outside Ebbing, Missouri
Best film, musical or comedy: Lady Bird
Best director: Guillermo del Toro, The Shape of Water
Best actor, drama: Gary Oldman, Darkest Hour
Best actress, drama: Frances McDormand, Three Billboards Outside Ebbing, Missouri
Best actor, musical or comedy: James Franco, The Disaster Artist
Best actress, musical or comedy: Saoirse Ronan, Lady Bird
Best supporting actor: Sam Rockwell, Three Billboards Outside Ebbing, Missouri
Best supporting actress: Allison Janney, I, Tonya
Best screenplay: Martin McDonagh, Three Billboards Outside Ebbing, Missouri
Best foreign language film: In the Fade
Best animated feature: Coco
Best original score: Alexandre Desplat, The Shape of Water
Best original song: Benj Pasek and Justin Paul, This Is Me from The Greatest Showman
TELEVISION
Best drama series: The Handmaid's Tale
Best drama actor: Sterling K. Brown, This is Us
Best drama actress: Elisabeth Moss, The Handmaid's Tale
Best musical or comedy series: The Marvelous Mrs. Maisel
Best musical or comedy actor: Aziz Ansari, Master of None
Best musical or comedy actress: Rachel Brosnahan, The Marvelous Mrs. Maisel
Best limited series or TV movie: Big Little Lies
Best limited series or TV movie actor: Ewan McGregor, Fargo
Best limited series or TV movie actress: Nicole Kidman, Big Little Lies
Best supporting actor in a series, limited series or TV movie: Alexander Skarsgard, Big Little Lies
Best supporting actress in a series, limited series or TV movie: Laura Dern, Big Little Lies