The Socceroos rising star was given his maiden taste of Scottish football at the Accies Hope CBD Stadium home ground, starting the match on the left wing for Celtic's second team.
While it was a poor performance from The Hoops reserves, Arzani provided fans with plenty to be bullish about after a number of slick touches during a 62 minute performance.
Celtic were out played in the match and conceded twice in quick succession to be down 2-0 after 20 minutes.
Hamilton wrapped up the win 15 minutes from time with a free-kick from 20 yards out.
Arzani was substituted after 62 minutes but had a strong outing coming close to scoring on two occasions.
The 19-year-old's speed and dribbling proved difficult for the Hamilton defence to contain, yet Arzani was unable to help his side find a breakthrough.
The match was Arzani's first since he came on for the Socceroos at the World Cup in Russia.
More matches in the reserve team are likely for the former Melbourne City player until he reaches full match fitness.
