The 29-year-old has hit 19 goals this season to help take Leicester five points clear at the top of the Premier League.
With skipper Wayne Rooney absent with a knee injury, Vardy is in line to pick up his fifth England cap at the Olympiastadion as he looks to break his international duck.
And, as well as attracting plenty of praise back home, it appears his exploits have also made an impression on the reigning world champions - with Low well aware of the threat the former non-league forward poses.
"We did watch him and he is a spectacular player," he said.
"A great performance, we did talk about him the last couple of days, not only him, but he is a player who is straightforward and is always looking to find the gap in the defence and get in behind the defence.
"That is where it hurts the most and I think that is one of his biggest qualities."
Vardy may yet have to settle for a place on England's bench despite scoring in 11 consecutive Premier League games earlier in the season to set a new record, as Harry Kane is enjoying his own purple patch at present.
The Tottenham striker tops the Premier League scoring charts with 21 - including five in his last three games - and Low knows the 22-year-old can also cause damage.
"Kane could play as well," he added. "I'm not sure if they have played together already. It could really impact our defence and it will be a different game if Kane or Vardy is playing - he is a fantastic player."
Vardy has been joined in Roy Hodgson's latest England squad by Leicester team-mate Danny Drinkwater, who is set to make his debut either against Germany or against Holland.
But another of the players helping Claudio Ranieri's Foxes into a league-winning position has been German defender Robert Huth.
The former Chelsea man has not been capped by his country in almost a decade but Low says, if necessary, he would have no qualms bringing Huth back into the fold.
"I'm very happy about his performances in the Premier League, he has always been a great player and had great performances in our team," he said of the 31-year-old.
"I know if something happens with our defenders we can call him. We do have a lot of defenders in our pocket but we could call him.
"He is a really good central defender and I would be happy if he wins the Premier League."
With the summer's European Championship on the horizon, both Low and Hodgson could experiment on Saturday night - and the Germany coach knows their old foes can offer a threat.
"England has improved a lot recently due to the coach Roy Hodgson, he had a big impact on the team" he said.
"I have known him for sometime, also in Switzerland, the team has always been well coordinated, it is difficult for us to play against them and they are really good on the counter-attack."