The 29-year-old had been due to go up against top Tour de France rivals Alberto Contador (Tinkoff-Saxo), Vincenzo Nibali (Astana) and Natro Quintana (Movistar) in the week-long Italian race, which starts on Wednesday.
Kanstantsin Siutsou replaces Froome on the Sky roster for Tirreno-Adriatico, joining Vasil Kiryienka, Leopold Konig, Mikel Nieve, Wout Poels, Salvatore Puccio, Kanstantsin Siutsou, Ian Stannard and Elia Viviani.
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