The South African rode for its pro-continental incarnation, MTN-Qhubeka from 2013-15.
Placing eighth overall at the Tour de France this season with UAE Emirates and last year with its precursor team Lampre-Merida, both Dimension Data and Meintjes believe a podium place at a grand tour is within reach.
"I want to thank Doug Ryder and Team Dimension Data for believing in me," Meintjes said. "Together, we can take Africa’s team to the top step of the podium by 2020."
"My choice to come home was easy, as Team Dimension Data stands out from other professional teams. They don’t only ride to win, but also for a more important cause - to mobilise people on bicycles in Africa.
"In the past two years I’ve gained tremendous experience from a European team, and I aim to use that experience to contribute to the success of Team Dimension Data for Qhubeka."
Team principal Ryder echoed his new signing's sentiments.
"Louis was a part of our initial journey and we are delighted to have him rejoin our team as we embark on the next part of the team’s dream," Ryder said.
"Our aim is to podium at a grand tour and to go beyond the magic number of 100,000 bicycles distributed through the Qhubeka charity to people in communities."
"We believe that Louis has the potential to stand on the top step of the podium in the World Tour stage races taking African cycling development to new heights."
