The BBC reports that watches, mobile phones and car keys were all stolen from Mane's house in south Liverpool.
The incident occurred while no one was at the property, with 26-year-old Mane in action at the time for Liverpool against German champions Bayern, which ended 0-0.
It was not the first time his house had been targeted since he moved to Liverpool, with Mane also burgled during a home Champions League game against Slovenian side Maribor in November, 2017.
"We are appealing for anyone with information in relation to this burglary to please come forward and assist our inquiries," Detective Inspector Phil Mahon of Merseyside Police told the BBC.
"While the occupants were not present at the time of the incident this will no doubt be a distressing experience for them and I would ask the offenders to do the right thing and return the stolen items to the owner in any way possible.
"We know the watches in particular are of significant monetary value and I would also like to appeal to anyone who might have been offered the items for sale since the burglary to contact police."
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