"Football is like this. It is about scoring goals and they scored three and we scored none but the performance was really good, the boys played a super game to be honest but against a side like Barcelona, a few moments are enough to give them the opportunity," Klopp said.
"What can I say? I am really happy with the performance but of course not too happy with the result, we have to take that, that’s football and we know that. You don’t get grades, only a hard result and we have to accept that."
Liverpool went in 1-0 down at the break but after dominating the early part of the second half, Messi struck twice including a superb long-range free kick.
"In these moments, he's unstoppable," Klopp told a news conference.
"Obviously we couldn't defend the free-kick. What a strike. He's a world-class player.
"The second goal – the 2-0 – was probably not the nicest goal in the career of Lionel Messi but it shows his skills that he's there in that moment. But apart from that I was happy with how we defended.
"I'm a big admirer of him but my boys tonight didn't show too much respect. They were there, tried with completely legal things. We didn't treat him harshly or whatever to try to get him out of the game. We played just football and I like that.
"I knew before that Lionel is a world-class player and now I saw it again. I'm not too surprised, to be honest."
Klopp's side had their chances too with James Milner having two shots saved and Mohamed Salah striking the post.
"That is how it is. How we created the moments was outstanding, how we caused them problems was outstanding, we controlled the game so well," Klopp said.
"We went in at halftime, analysed the half, told the boys what we can do better and what have to do it again. I don’t know if we can play it much better to be honest," he said.
"But then you have that one moment, the ball hits the crossbar….. and then Messi is there for an easy goal. Then a wonder strike again, that is how it is. That ball was obviously unsaveable," Klopp added.
"Barcelona showed they had more experience. We saw that in the moments when they stopped our rhythm, going down, but that's part of the game," the German said.
Liverpool must now try to turn the game around at Anfield, an even harder task without an away goal.
"3-0 is not the easiest result but we have another game (second leg) and our people will be there," he said.
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