The England winger picked up the injury in the UEFA Champions League defeat to Barcelona and will miss the trip to Old Trafford with boss Arsene Wenger uncertain of when he will be back.
Defender Gabriel will undergo a fitness test ahead of the game as he looks to return from a hamstring problem, while Jack Wilshere (leg), Santi Cazorla (knee) and Tomas Rosicky (thigh) are all still missing.
Provisional squad: Cech, Ospina, Monreal, Gibbs, Koscielny, Gabriel, Mertesacker, Bellerin, Chambers, Ramsey, Elneny, Coquelin, Flamini, Ozil, Reine-Adelaide, Iwobi, Sanchez, Campbell, Walcott, Welbeck, Giroud.
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