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Mane hobbled off in the 20th minute of Bayern Munich's eventual 6-1 victory over Werder Bremen, with L'Equipe later confirming the forward would miss the entire tournament in Qatar.
The defending Bundesliga champions are yet to confirm such reports, however, and remain in contact with Senegalese officials ahead of their opening match against the Netherlands on November 22.
"Sadio Mane suffered an injury to the head of his right fibula in FC Bayern's 6-1 win against Werder Bremen," the club said in a statement.
"Africa's Footballer of the Year will miss Saturday's game against Schalke. Further examinations will follow in the coming days.
"FC Bayern is also in contact with the medical staff of the Senegalese Football Association."
Senegal's confirmed squad for the World Cup signals the return of Chelsea goalkeeper Édouard Mendy to the fold after the player missed the nation's previous two internationals in September with a knee injury.
His teammate and national team captain, Kalidou Koulibaly, Watford attacker Ismaïla Sarr and Premier League midfielders Idrissa Gueye (Everton) and Cheikhou Kouyaté (Nottingham Forest) were also among those named in the squad.
Goalkeepers: Edouard Mendy, Alfred Gomis, Seny Diang
Defenders: Bouna Sarr, Saliou Ciss, Kalidou Koulibaly, Pape Abou Cisse, Abdou Diallo, Ibrahima Mbaye, Abdoulaye Seck, Fode Ballo Toure, Cheikhou Kouyate
Midfielders: Pape Matar Sarr, Pape Gueye, Nampalys Mendy, Idrissa Gana Gueye, Moustapha Name, M. Loum Ndiaye, Joseph Lopy
Forwards: Sadio Mane, Ismaila Sarr, Bamba Dieng, Keita Balde, Habib Diallo, Boulaye Dia, Famara Diedhiou, Mame Babe Thiam
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Every confirmed FIFA World Cup squad
