Israel says it has also intercepted what it says is an Iranian drone in response to the downing of one of its F16 warplanes.
The incidents mark the most serious confrontations in Syria between Israel and Iranian-backed forces that have established a major foothold in the country while fighting in support of President Bashar al-Assad in the nearly seven-year-old civil war.
Iran's President Hassan Rouhani has told state TV countries are mistaken if they think bombing their neighbours can lead to desirable results.
While Israeli Prime Minister Binyamin Netanyahu has also addressed his people to defend Israel's actions.
The United States says it fully supports Israel's right to defend itself against threats.
An interview with Syrian political analyst Adnan Abdul Razzak from Istanbul.
