The Peugeot's driver is in hospital after suffering serious chest injuries, while the other car's driver suffered only minor injuries.
Victoria Police, in a media statement, said "emergency services responded to a collision in Pine Lodge near Shepparton that has left four people dead."
Police said that the driver of the ute was not seriously injured and stopped to assist at the scene.
A road tragedy involving two cars has left four people dead in Victoria this week. (Representative image) Source: Moment RF / Benjamin Probert/Getty Images
Police confirmed that three of the four men killed in the crash were not wearing seatbelts and were thrown from their car.
"Tragically, the three men in the rear seat of Peugeot car who were ejected from the vehicle, have died. The front seat passenger who wasn't ejected but was trapped in the car, also died at the scene," Acting Assistant Commissioner for Road Policing Justin Goldsmith told SBS Hindi.
"The driver of the Peugeot car has undergone a surgery at the Royal Melbourne hospital and will be released in coming days," he said, while confirming that all four of the people who died were of Indian background.
The Major Collision Investigation team were at the scene to probe the incident and Mr Goldsmith said police will be speaking to both drivers once they are medically cleared.
Victoria police official Justin Goldsmith urges drivers to be vigilant on road and wear seatbelts. Source: Moment RF / Patcharanan Worrapatchareeroj/Getty Images
"Wearing a seatbelt is mandatory in Victoria and it is like second nature to Victorians who are born and brought up here. Even if you are here for shorter period of time, you should make yourself aware of traffic rules," he said.
Traffic rules in Victoria are strictly enforced, and the penalty for not wearing a seatbelt is almost $370.
Mr Goldsmith also urged drivers to be more vigilant on the road and to drive responsibly.
