Earlier in the men's draw, Argentina's Guido Pella eliminated last year's finalist and South African sixth seed Kevin Anderson 6-4 6-3 7-6 (7-4) result on Centre Court.
Tenth seed Karen Khachanov also exited following a 6-3 7-6 (7-3) 6-1 defeat to Spain's Roberto Bautista-Agut.
Canada's Milos Raonic entered the second week of the tournament after he dispatched American Reilly Opelka 7-6 (7-1) 6-2 6-1, with the 2016 finalist to next face Anderson's conqueror Pella.