"It will be a war," the Belgian told British media. "We go there in a very positive way.
"You want to win this game, you know it will not be easy, it is a derby so it will be special and a very big and important game for us as a club. We have to prepare it well."
Everton will be missing the experience of captain Phil Jagielka, who is suspended after being sent off during their 2-1 win over Arsenal in midweek, with defender Ramiro Funes Mori likely to return to the starting lineup.
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In Liverpool's last meeting with Everton, a 4-0 win at Anfield in April, the Belgian was on the receiving end of a heavy challenge from Funes Mori that kept him sidelined for a month, although Origi said the Argentine had since apologised.
"These are things that happen," Origi said. "I came back stronger and I have to continue growing.
"I received an official message (from Funes Mori). I keep on looking forward and I am very excited for the next game.
"How will I feel? I don't know who is playing but I am very motivated."
A victory in the 227th Merseyside derby would allow Liverpool to leapfrog Manchester City and sit six points adrift of leaders Chelsea.
(Reporting by Hardik Vyas in Bengaluru)
