United, who are unbeaten in their last eight league games, are sixth in the table, and have not lost at home since their 2-1 defeat by Manchester City on Sept. 10.
"We are going up against some top, top players," Pickford told the club website. (www.safc.com).
"We have got to go there and show we don't fear them.
"We have to stick to our game plan, keep a clean sheet and then... anything can happen. We'll have a good week of training, we'll go there with a game plan and hopefully that works out for us on the day."
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Sunderland's clean sheet against Watford was their second in the league this season and with goals hard to come by at the other end, Pickford said the defence needed to tighten up further.
Sunderland have scored 15 goals in 17 league games, with only basement side Hull City scoring fewer.
"It's nice to get a clean sheet because I'm not getting them as much as I would like to," Pickford added.
"I will take each clean sheet as it comes because from a goalkeeper's point of view there is definitely nothing better than that."
After United, Sunderland visit Burnley on Dec. 31 before hosting second-placed Liverpool on Jan. 2.
(Reporting by Hardik Vyas in Bengaluru)
