The Watford winger limped off in the second half of last Sunday's 4-1 home loss to Tottenham and, after medical examinations, was ruled out of the tournament in Gabon, which starts next weekend.
The 26-year-old Belgian-born El Kaddouri has won 22 caps for Morocco, having first made his debut in 2013.
Morocco open their Nations Cup campaign against the Democratic Republic of Congo in Group C in Oyem on Jan. 16. They have a warm-up international against Finland in the United Arab Emirates on Sunday.
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(Reporting by Mark Gleeson in Cape Town; Editing by John O'Brien)
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