France's Six Nations preparations have been hit by another injury with centre Yann David pulling out of the squad ahead of Saturday's opening match against England.
France has been rocked by a spate of withdrawals and David, who hurt his thigh in training on Tuesday, now joins the list.
The French Rugby Federation said that David had to pull out following medical tests, adding that he will not be replaced before the match at Twickenham.
David, who is a reserve centre, is also doubtful for the home game against Scotland on February 12.
France coach Guy Noves only has three fit centres to face England and must choose between Gael Fickou, Remi Lamerat and Mathieu Bastareaud.
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Flanker Raphael Lakafia, hooker Camille Chat, loosehead prop Eddy Ben Arous and star centre Wesley Fofana previously withdrew from the squad.
France is also without experienced fly-half Francois Trinh-Duc who is recovering from a broken arm.
