"Derbies are always a must-win game," Negredo told the club website (www.mfc.co.uk). "This game is very important as a derby but also in the circumstances.
"Things can be turned around if we win and it can be a real boost for the next few games.
"Obviously, it's a very difficult situation... we have to stick together, and keep fighting because we still have a chance."
David Moyes' Sunderland have won just twice on the road all season and have an opportunity to go level on points with the Teesside outfit at the Riverside Stadium.
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Middlesbrough won the reverse fixture 2-1 in August at the Stadium of Light with Negredo creating both the goals for Cristhian Stuani.
(Reporting by Hardik Vyas in Bengaluru; editing by Sudipto Ganguly)
